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	Provedor de dados Nature Precedings (2) Autor Wade Bushman (2) Aubie Shaw (1) Dan Theodorescu (1) Jerry Gipp (1) Travis Jerde (1) Zhong Wu (1) Mais... Palavra-chave Cancer (2) Developmental Biology (2) Tipo do documento Manuscript (2) Ano 2010 (1) 2009 (1) País United Kingdom (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Regulation of Phosphatase Homologue of Tensin Protein Expression by Bone Morphogenetic Proteins in Prostate Epithelial Cells Nature Precedings Travis Jerde; Zhong Wu; Dan Theodorescu; Wade Bushman. Phosphatase homologue of tensin (PTEN) is the key endogenous inhibitor of phosphoinositide signaling and is the most commonly mutated gene in human prostate cancer. The bone morphogenetic proteins (BMPs) are secreted developmental signaling molecules known to promote differentiation in the prostate. BMP ligands have been shown to inhibit prostate cancer cell line proliferation and tumor growth and expression of BMPs, BMP ligands, receptors and signaling effectors are diminished in prostate cancer. A previous report in the colon led us to investigate the potential mechanistic relationship between PTEN and BMP signaling in prostate epithelial cells. We show here that BPM signaling positively regulates PTEN in normal and malignant prostate cells by increasing... Tipo: Manuscript Palavras-chave: Cancer; Developmental Biology. Ano: 2010 URL: http://precedings.nature.com/documents/4311/version/1 The Sonic Hedgehog Pathway Stimulates Prostate Tumor Growth by Paracrine Signaling and Recaptures Embryonic Gene Expression in Tumor Myofibroblasts Nature Precedings Aubie Shaw; Jerry Gipp; Wade Bushman. The Hedgehog (Hh) pathway contributes to prostate cancer growth and progression. The presence of robust Shh expression in both normal prostate and localized cancer challenged us to explain the unique growth promoting effect in cancer. We show here that paracrine Hh signaling exerts a non-cell autonomous effect on xenograft tumor growth and that Hh pathway activation in myofibroblasts alone is sufficient to stimulate tumor growth. Nine genes regulated by Hh in the mesenchyme of the developing prostate were found to be regulated in the stroma of Hh over-expressing xenograft tumors. Correlation analysis of gene expression in matched specimens of benign and malignant human prostate tissue revealed a partial 5 gene fingerprint of Hh-regulated expression in... Tipo: Manuscript Palavras-chave: Cancer; Developmental Biology. Ano: 2009 URL: http://precedings.nature.com/documents/3682/version/1 Registros recuperados: 2 Primeira ... 1 ... Última

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