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| Cui,Xin; Sun,Zheng-Rong; Ren,Gao-Wei; Wang,Gui-Li; Qi,Ying; Ma,Yan-Ping; Ruan,Qiang. |
| Interplay between the host and human cytomegalovirus (HCMV) has a pivotal role in the outcome of infection. A region (referred to as UL/b’) present in the Toledo strain of HCMV and low passage clinical isolates contains 19 additional genes, which are absent in the highly passaged laboratory strain AD169. Products of the UL/b’ genes may determine the manifestations of HCMV infection in vivo. However, little is known about the host factors, which interact with UL/b’ proteins. This study was conducted to investigate the function of the HCMV UL136 protein. By yeast two-hybrid screening, the β1 subunit of the host Na+/K+-ATPase (ATP1B1) was identified to be a candidate protein, which interacts with the HCMV UL136 protein. The interaction was further evaluated... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HCMV; UL136; ATPase; Yeast two hybridization. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001200008 |
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