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	Provedor de dados BJMBR (1) Autor Chen,Y. (1) Liu,Y. (1) Miao,Z.M. (1) Wang,F. (1) Wang,Y.G. (1) Wang,Z.C. (1) Yu,X.L. (1) Mais... Palavra-chave Elongation of long-chain fatty acids family member 6 (1) Insulin resistance (1) Single nucleotide polymorphism (1) Type 2 diabetes mellitus (1) Β-cell function (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2013 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Genetic analysis of the ELOVL6 gene polymorphism associated with type 2 diabetes mellitus BJMBR Liu,Y.; Wang,F.; Yu,X.L.; Miao,Z.M.; Wang,Z.C.; Chen,Y.; Wang,Y.G.. Recent animal studies have indicated that overexpression of the elongation of long-chain fatty acids family member 6 (Elovl6) gene can cause insulin resistance and β-cell dysfunction. These are the major factors involved in the development of type 2 diabetes mellitus (T2DM). To identify the relationship between single nucleotide polymorphisms (SNP) ofELOVL6 and T2DM pathogenesis, we conducted a case-control study of 610 Han Chinese individuals (328 newly diagnosed T2DM and 282 healthy subjects). Insulin resistance and islet first-phase secretion function were evaluated by assessment of insulin resistance in a homeostasis model (HOMA-IR) and an arginine stimulation test. Three SNPs of the ELOVL6 gene were genotyped with polymerase chain reaction-restriction... Tipo: Info:eu-repo/semantics/article Palavras-chave: Elongation of long-chain fatty acids family member 6; Single nucleotide polymorphism; Type 2 diabetes mellitus; Insulin resistance; Β-cell function. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000700623 Registros recuperados: 1 Primeira ... 1 ... Última

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