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| Xiao-Jing Li; Wei Zhang; Bing Liang; Xiang Zheng; Xue Zhou. |
| It is believed that the hypothalamus is the regulating center for blood glucose levels, but how chronic stress leads to hyperglycemia is not known. In this experiment, we use the chronic immobilization stressed rat as a model, and found that only rats with increased expression of GAD65 in the amygdala have an elevated level of blood glucose. Considering there are fiber tracks between the amygdala and hypothalamus, including GABAergic projections, this result suggests that the changes in GAD65 expression in the amygdala may correlate with the changes in blood glucose levels, and point to the importance of the the amygdala in blood glucose regulation. |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5885/version/1 |
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| Wei Zhang. |
| Genome-wide associations between genotypic and phenotypic data often assume certain genetic models. A handy script in R was written to implement three commonly used genetic models: additive, dominant and recessive models. This script can be easily inserted into more complicated programs to facilitate high-throughput association studies. |
| Tipo: Manuscript |
Palavras-chave: Bioinformatics. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1537/version/1 |
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| Wei Zhang. |
| Genome-wide associations between genotypic and phenotypic data often assume certain genetic models. A handy script in R was written to implement three commonly used genetic models: additive, dominant and recessive models. This script can be easily inserted into more complicated programs to facilitate high-throughput association studies. |
| Tipo: Manuscript |
Palavras-chave: Bioinformatics. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1537/version/2 |
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| Wei Zhang. |
| Understanding of the mechanism of DNA mutation process is critical for studying the functional consequences of genetic variation in clinical medicine (eg. drug response) as well as other complex traits (eg. gene expression and cause of common diseases). During the last several decades, many probabilistic models of DNA nucleotide substitution have been proposed for studying this process. A common feature of these mutation models is that they assume the nucleotides evolve independently at each site. In other words, they are sequence context-independent models. However, based on various biochemical studies, it is now recognized that the DNA mutation process resulting in substitutions in both coding and non-coding regions may depend on sequence context. We... |
| Tipo: Presentation |
Palavras-chave: Ecology; Bioinformatics; Evolutionary Biology. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1243/version/1 |
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