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| Vassallo,D.V.; Simões,M.R.; Furieri,L.B.; Fioresi,M.; Fiorim,J.; Almeida,E.A.S.; Angeli,J.K.; Wiggers,G.A.; Peçanha,F.M.; Salaices,M.. |
| Heavy metals have been used in a wide variety of human activities that have significantly increased both professional and environmental exposure. Unfortunately, disasters have highlighted the toxic effects of metals on different organs and systems. Over the last 50 years, the adverse effects of chronic lead, mercury and gadolinium exposure have been underscored. Mercury and lead induce hypertension in humans and animals, affecting endothelial function in addition to their other effects. Increased cardiovascular risk after exposure to metals has been reported, but the underlying mechanisms, mainly for short periods of time and at low concentrations, have not been well explored. The presence of other metals such as gadolinium has raised concerns about... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Heavy metal toxicity; Vascular reactivity; Mercury; Lead; Gadolinium. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900016 |
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| Vassallo,D.V.; Lebarch,E.C.; Moreira,C.M.; Wiggers,G.A.; Stefanon,I.. |
| Lead (Pb2+) poisoning causes hypertension, but little is known regarding its acute effects on cardiac contractility. To evaluate these effects, force was measured in right ventricular strips that were contracting isometrically in 45 male Wistar rats (250-300 g) before and after the addition of increasing concentrations of lead acetate (3, 7, 10, 30, 70, 100, and 300 µM) to the bath. Changes in rate of stimulation (0.1-1.5 Hz), relative potentiation after pauses of 15, 30, and 60 s, effect of Ca2+ concentration (0.62, 1.25, and 2.5 mM), and the effect of isoproterenol (20 ng/mL) were determined before and after the addition of 100 µM Pb2+. Effects on contractile proteins were evaluated after caffeine treatment using tetanic stimulation (10 Hz) and measuring... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lead; Right ventricular strips; Contraction; Heart; Myosin ATPase activity. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000900008 |
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