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	Provedor de dados Nature Precedings (2) Autor William D. Klipec (2) Abby Drish (1) Andrew L. Varnell (1) Bridget Deeney (1) Claire Williamson (1) Donald C. Cooper (1) Donald C. Cooper (1) Eric Ostertag (1) Eric M. Ostertag (1) Jessica Stumme (1) Kami Wenzel (1) Kurt R. Illig (1) Laura Swenson (1) Marissa Collins (1) Phuong Nguyen (1) Mais... Palavra-chave Neuroscience (2) Pharmacology (2) Genetics & Genomics (1) Tipo do documento Manuscript (2) Ano 2012 (1) 2011 (1) País United Kingdom (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Deletion of the trpc4 gene and its role in simple and complex strategic learning Nature Precedings William D. Klipec; Phuong Nguyen; Bridget Deeney; Claire Williamson; Kami Wenzel; Jessica Stumme; Marissa Collins; Abby Drish; Laura Swenson; Eric Ostertag; Donald C. Cooper. The TRPC4 ion channel is expressed extensively in corticolimbic and a subpopulation of midbrain dopamine neurons. While TRPC4 knockout (KO) rats exhibit reduced sociability and social exploration, little is known about the role of TRPC4 in motivation and learning. To identify a function for TRPC4 channels in learning processes  we tested TRPC4 KO and normal wild type (WT) rats. TRPC4 KO and WT rats exhibited no differences in Y-­maze learning or simple discrimination learning. Furthermore, on a more complex serial reversal shift task designed  to assess strategic learning where the reward and non-­reward cues were repeatedly reversed between training sessions both TRPC4 KO and WT rats  ... Tipo: Manuscript Palavras-chave: Neuroscience; Pharmacology. Ano: 2012 URL: http://precedings.nature.com/documents/6929/version/1 TRPC4 ion channel protein is selectively expressed in a subpopulation of dopamine neurons in the ventral tegmental area Nature Precedings Kurt R. Illig; Andrew L. Varnell; Eric M. Ostertag; William D. Klipec; Donald C. Cooper. The nonselective cation channel TRPC4 has been shown to be present in high abundance in the corticolimbic regions of the brain and play a pivotal role in modulating cellular excitability due to their involvement in intracellular Ca^2+^ regulation. Recently we reported their involvement in socialization and regulating anxiety-like behaviors in rats. Given the important role for dopamine in modulating emotions involved in social anxiety we investigated whether TRPC4 protein and mRNA was found on dopaminergic neurons of the ventral tegmental area (VTA). Using emulsion autoradiography we found that TRPC4 mRNA is indeed present in the VTA and the substantia nigra. Additionally, immunohistochemistry verified it’s presence on a subpopulation of... Tipo: Manuscript Palavras-chave: Genetics & Genomics; Neuroscience; Pharmacology. Ano: 2011 URL: http://precedings.nature.com/documents/6577/version/1 Registros recuperados: 2 Primeira ... 1 ... Última

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