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	Provedor de dados Nature Precedings (2) Autor William D. Klipec (2) Bridget Deeney (1) Claire Williamson (1) Donald C. Cooper (1) Eric Ostertag (1) Kami Wenzel (1) Phuong Nguyen (1) Steven Faux (1) Mais... Palavra-chave Neuroscience (2) Genetics & Genomics (1) Tipo do documento Manuscript (2) Ano 2012 (2) País United Kingdom (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última P300- like event related potential amplitude in rats is a correlate of conditioned reinforcement Nature Precedings William D. Klipec; Steven Faux. We have developed a methodology for recording a robust P300 event related potential (ERP) in rats. In these experiments a contingency shaped model of the human “oddball’ paradigm was employed in which rats were shaped to press a lever for food reinforcement signaled by the click of the pellet dispenser. A target tone cued the insertion of the lever that retracted after 1­sec or immediately following a single reinforced response, while a non­target tone was randomly presented. Brain activity was recorded through stainless steel electrodes implanted 1mm below the skull. Here, we compared the amplitude of the P300 response to the click of the pellet dispenser to the amplitude of the P300 response to the target and... Tipo: Manuscript Palavras-chave: Neuroscience. Ano: 2012 URL: http://precedings.nature.com/documents/7100/version/1 Deletion of the rat trpc4 gene and its influence on motivated responding for natural reward Nature Precedings William D. Klipec; Bridget Deeney; Claire Williamson; Kami Wenzel; Phuong Nguyen; Eric Ostertag; Donald C. Cooper. TRPC4 ion channels are expressed extensively in corticolimbic brain regions and a subpopulation of midbrain dopamine neurons. TRPC4 knockout (KO) rats show reduced sociability and social exploration, but show no differences in simple and complex strategic learning compared to normal wild type (WT) rats. Using water reward, we found no differences between TRPC4-KO and WT rats in the break point on a progressive ratio schedule of reinforcement. Although deletion of the trpc4 gene alters social interaction/anxiety it does not appear to affect motivation for natural rewards. Current experiments are underway testing the role of trpc4 gene deletion on cocaine reward (see www.neuro-cloud.net/nature-precedings/klipec3 for updates and collaborations). Tipo: Manuscript Palavras-chave: Genetics & Genomics; Neuroscience. Ano: 2012 URL: http://precedings.nature.com/documents/7109/version/1 Registros recuperados: 2 Primeira ... 1 ... Última

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