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	Provedor de dados Genet. Mol. Biol. (1) Autor Moraes,Karen C.M. (1) Wilusz,Carol J. (1) Wilusz,Jeffrey (1) Palavra-chave 3'UTR (1) CUG-BP (1) Deadenylation (1) MRNA decay (1) MRNA stability (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2007 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última CUG-BP and 3'UTR sequences influence PARN-mediated deadenylation in mammalian cell extracts Genet. Mol. Biol. Moraes,Karen C.M.; Wilusz,Carol J.; Wilusz,Jeffrey. Several mRNAs have been shown to exhibit distinct patterns of poly(A) shortening prior to their decay in vivo. In this study, we show that individual transcripts also demonstrate distinct patterns of deadenylation in in vitro systems derived from HeLa and Jurkat T cell cytoplasmic extracts. The major patterns observed were slow/synchronous and fast/asynchronous poly(A) tail shortening. For all RNA substrates tested, PARN was shown to be the enzyme responsible for the deadenylation patterns that were observed. Sequences in the 3' untranslated regions influenced the deadenylation pattern. Using a fragment of the 3'UTR of the c-fos mRNA as a model, the interaction of CUG-BP, the human homolog of EDEN-BP - a protein previously implicated in regulated... Tipo: Info:eu-repo/semantics/article Palavras-chave: MRNA decay; Deadenylation; MRNA stability; 3'UTR; CUG-BP. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000400024 Registros recuperados: 1 Primeira ... 1 ... Última

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