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Metabolic analysis of the effect of rheum on a taurocholate-induced acute pancreatitis rat model BJPS
Chen,Zhonghua; Shen,Li; Yang,Changyong; Jiang,Jinghui; Liu,Xing.
ABSTRACT The effects of rheum on serum parameters in a taurocholate-induced acute pancreatitis (AP) rat model were investigated using pathological and biochemical tests, and a proton nuclear magnetic resonance (1H NMR)-based metabonomic strategy. Healthy rats and rats with AP were either treated with rheum (7.5% at a dose of 1.5 g/kg) or left untreated. Serum samples were collected from the AP and rheum-treated groups at 6, 12, and 24 h after treatment. The effect of rheum on pathological changes in the pancreatic was investigated to validate the AP model. We obtained 1H NMR spectra and analyzed the results using the partial least squares discriminant method. The results of the pathological and metabolic analyses revealed an amelioration of multiple...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rheum/effects; Acute pancreatitis/analysis; Metabolomics; 1H NMR; Pathological changes; Rats.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200633
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