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| Xu,Xianrong; Lu,Jing; Sheng,Hongqiang; Zhang,Long; Gan,Tieer; Zhang,Jianyun; Xu,Yuying; Zhu,Xinqiang; Yang,Jun. |
| The melamine and cyanuric acid (CA) complex has been suggested to cause the toxic effects observed in melamine-contaminated food or milk. However, the cytotoxic and genotoxic effects of co-exposure to melamine and CA are not fully clear. Therefore, the cytotoxic effects of melamine and CA were first examined by co‐exposure in human kidney 293 cells using the MTT assay. During a 24-h period for the three concentrations tested (0.5, 1, and 5 mg/mL), neither melamine nor CA alone showed significant toxic effects on 293 cells at 0.5 mg/mL, while higher concentrations led to decreased in cell viability. However, co-exposure to several combinations of melamine and CA [100:1, 10:1, 1:10, and 1:100 (v:v), at a final concentration of 0.5 mg/mL] did cause... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Melamine; Cyanuric acid; ΓH2AX; DNA damage; Genotoxicity. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000500612 |
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| Yan,Xi-Qing; Chen,Zhi-Gang; Wang,Rong-Liang; Yang,Jun; Ai,Fang; Pan,Yan-Juan; Qiu,Pei-Yong; Wang,Da-Xin. |
| The pharmacokinetics (PK) of ordinary tablets and sustained release capsules of diltiazem hydrochloride in human clinical trials had been studied. The PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules, a new dosage form, has not been reported, although it is very important to clinical use. In this paper, we investigated the PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules and the food influence in Chinese healthy volunteers. The PK parameters indicated that the diltiazem hydrochloride delay-onset sustained-release pellet capsules appeared marked characteristics of delayed and controlled release. An opened-label, randomized and parallel clinical trial was conducted in 36 Chinese healthy volunteers with... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diltiazem hydrochloride/delay-onset sustained-release pellet capsules; Diltiazem hydrochloride/pharmacokinetics; Food/ingestion; Food/effect in pharmacokinetic profile; High-performance liquid chromatography/quantitative analysis. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100004 |
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