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| Xu,Qing; Liu,Lei; Yang,Yiqiong; Wang,Zhi; Cai,Yingying; Hong,Tingting; Chen,Pingsheng. |
| Rab7, an important member of the Rab family, is closely related to autophagy, endocytosis, apoptosis, and tumor suppression but few studies have described its association with renal fibrosis. In the early stage, our group studied the effects of Rab7 on production and degradation of extracellular matrix in hypoxic renal tubular epithelial cells. Because cell culture in vitro is different from the environment in vivo, it is urgent to understand the effects in vivo. In our current study, we established a renal fibrosis model in Rab7-knock-in mice (prepared by CRISPR/Cas9 technology) and wild type (WT) C57BL/6 mice using unilateral ureteral obstruction (UUO). Seven and 14 days after UUO, the expression of the Rab7 protein in WT mice, as well as the autophagic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rab7; Autophagy; Renal fibrosis; Crispr/cas9; Endocytosis; Lipophagy. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000400603 |
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