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	Provedor de dados BJMBR (2) Autor Yang,Z. (2) Chen,Y. (1) Liu,F.Q. (1) Mu,J.J. (1) Peng,Y. (1) Ren,K.Y. (1) Wang,Y. (1) Xiao,H.Y. (1) Yang,S. (1) Yuan,Z.Y. (1) Mais... Palavra-chave Chronic hepatitis B (1) Cirrhosis (1) Dahl salt-sensitive rats (1) EMT (1) Fibrosis (1) High salt intake (1) IL-6 receptor (1) MiRNA-30b (1) Renal fibrosis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2017 (1) 2014 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última The regulatory role of IL-6R in hepatitis B-associated fibrosis and cirrhosis BJMBR Chen,Y.; Yang,S.; Peng,Y.; Yang,Z.. This study investigated the expression and regulation of IL-6R in hepatitis B-associated moderate hepatic fibrosis and cirrhosis. Liver tissues, peripheral blood monocytes (PBMs) and serum were collected from 26 hepatitis B patients with liver fibrosis and 35 hepatitis B patients with liver cirrhosis. The levels of Il-6r mRNA expression in these samples were examined by quantitative real-time PCR and IL-6R protein levels were analyzed by western blot and ELISA. MiRNAs that regulate IL-6R expression were predicted by bioinformatics analysis, and validated by dual luciferase reporter assay. Compared with the hepatic fibrosis group, IL-6R was significantly upregulated at both mRNA and protein levels in liver tissues, PBMs and serum samples from the hepatic... Tipo: Info:eu-repo/semantics/article Palavras-chave: MiRNA-30b; IL-6 receptor; Chronic hepatitis B; Fibrosis; Cirrhosis. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100610 Salt-induced epithelial-to-mesenchymal transition in Dahl salt-sensitive rats is dependent on elevated blood pressure BJMBR Wang,Y.; Mu,J.J.; Liu,F.Q.; Ren,K.Y.; Xiao,H.Y.; Yang,Z.; Yuan,Z.Y.. Dietary salt intake has been linked to hypertension and cardiovascular disease. Accumulating evidence has indicated that salt-sensitive individuals on high salt intake are more likely to develop renal fibrosis. Epithelial-to-mesenchymal transition (EMT) participates in the development and progression of renal fibrosis in humans and animals. The objective of this study was to investigate the impact of a high-salt diet on EMT in Dahl salt-sensitive (SS) rats. Twenty-four male SS and consomic SS-13BN rats were randomized to a normal diet or a high-salt diet. After 4 weeks, systolic blood pressure (SBP) and albuminuria were analyzed, and renal fibrosis was histopathologically evaluated. Tubular EMT was evaluated using immunohistochemistry and real-time PCR... Tipo: Info:eu-repo/semantics/article Palavras-chave: Dahl salt-sensitive rats; High salt intake; EMT; Renal fibrosis. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000300223 Registros recuperados: 2 Primeira ... 1 ... Última

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