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	Provedor de dados BJMBR (1) Autor Altuna,M.E. (1) Damasco,M.C. (1) Mac Laughlin,M.A. (1) Yeyati,N.L. (1) Palavra-chave 11β-HSD2 (1) 5/6 Nephrectomy (1) Aldosterone (1) Potassium excretion (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2010 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Role of 11β-hydroxysteroid dehydrogenase 2 renal activity in potassium homeostasis in rats with chronic renal failure BJMBR Yeyati,N.L.; Altuna,M.E.; Damasco,M.C.; Mac Laughlin,M.A.. Aldosterone concentrations vary in advanced chronic renal failure (CRF). The isozyme 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2), which confers aldosterone specificity for mineralocorticoid receptors in distal tubules and collecting ducts, has been reported to be decreased or normal in patients with renal diseases. Our objective was to determine the role of aldosterone and 11β-HSD2 renal microsome activity, normalized for glomerular filtration rate (GFR), in maintaining K+ homeostasis in 5/6 nephrectomized rats. Male Wistar rats weighing 180-220 g at the beginning of the study were used. Rats with experimental CRF obtained by 5/6 nephrectomy (N = 9) and sham rats (N = 10) were maintained for 4 months. Systolic blood pressure and plasma creatinine (Pcr)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aldosterone; 5/6 Nephrectomy; 11β-HSD2; Potassium excretion. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000100008 Registros recuperados: 1 Primeira ... 1 ... Última

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