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	Provedor de dados BJMBR (2) Autor Huang,Y. (2) Yi,C. (2) Cao,Y. (1) Chen,S.C. (1) Cui,D.D. (1) Cui,Y.X. (1) Huang,H. (1) Ji,L.L. (1) Mao,S.H. (1) Qiu,M. (1) Wang,S.R. (1) Xu,Y.Z. (1) Mais... Palavra-chave Apoptosis (2) Adriamycin (1) Breast cancer (1) Growth hormone (1) Insulin-like growth factor-1 (1) Intestinal mucosa barrier (1) Sepsis (1) Synergism (1) TRAIL (1) TRAIL receptors (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2009 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Synergistic antitumor effect of TRAIL and adriamycin on the human breast cancer cell line MCF-7 BJMBR Cui,D.D.; Huang,Y.; Mao,S.H.; Chen,S.C.; Qiu,M.; Ji,L.L.; Yi,C.. The aim of the present study was to determine the effect of the combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and adriamycin (ADM) on the human breast cancer cell line MCF-7 and to identify potential mechanisms of apoptosis. Cell viability was analyzed by the MTT assay and the synergistic effect was assessed by the Webb coefficient. Apoptosis was quantified using the annexin V-FITC and propidium iodide staining flow cytometry. The mRNA expression of TRAIL receptors was measured by RT-PCR. Changes in the quantities of Bax and caspase-9 proteins were determined by Western blot. MCF-7 cells were relatively resistant to TRAIL (IC50 >10 µg/mL), while MCF-7 cells were sensitive to ADM (IC50 <10 µg/mL). A subtoxic... Tipo: Info:eu-repo/semantics/article Palavras-chave: TRAIL; TRAIL receptors; Breast cancer; Adriamycin; Apoptosis; Synergism. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000900013 Beneficial effect of recombinant human growth hormone on the intestinal mucosa barrier of septic rats BJMBR Yi,C.; Cao,Y.; Wang,S.R.; Xu,Y.Z.; Huang,H.; Cui,Y.X.; Huang,Y.. The objective of the present study was to investigate the effects of recombinant human growth hormone (rhGH) on the intestinal mucosa barrier of septic rats and explore its possible mechanism. Female Sprague-Dawley rats were randomized into three groups: control, Escherichia coli-induced sepsis (S) and treatment (T) groups. Groups S and T were subdivided into subgroups 1d and 3d, respectively. Expression of liver insulin-like growth factor-1 (IGF-1) mRNA, Bcl-2 and Bax protein levels and the intestinal Bax/Bcl-2 ratio, and plasma GH and IGF-1 levels were determined. Histological examination of the intestine was performed and bacterial translocation was determined. rhGH significantly attenuated intestinal mucosal injuries and bacterial translocation in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Intestinal mucosa barrier; Growth hormone; Sepsis; Insulin-like growth factor-1; Apoptosis. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000100006 Registros recuperados: 2 Primeira ... 1 ... Última

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