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| Yi,Tingting. |
| ABSTRACT: Orally disintegrating tablets (ODTs) disintegrate rapidly in the mouth in seconds when placed at the tongue. The introduction of ODTs for dogs can address many needs, ranging from convenient dosing for dogs with dysphagia to extending life cycle of drugs. Now, different technologies are widely combined for developing ODTs. The combination makes ODTs have more properties, obtaining orally disintegrating sustained release tablets or orally disintegrating enteric tablets or enhancing the dissolution rate and bioavailability of poorly water-soluble drugs and so on. The aim of this article is to give a comprehensive prospect to the application of ODTs to dogs, including ideal properties of drugs, indications of ODTs, considerations in developing ODTs... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Orally disintegrating tablet; Indication; Consideration; Dogs. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000400602 |
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| Yi,Tingting. |
| ABSTRACT: The purpose of the study was to prepare orally disintegrating tablets (ODTs) of mosapride citrate for dogs with fast disintegration and low cost. The ODTs were developed by varying the components and the ratio of excipients. A direct compression method was used. The properties of the ODTs, including hardness, friability, active ingredient content, and in vitro disintegration time, were investigated, and an economic analysis of the formulations was performed. For all formulations, friability was less than 1%, and the hardness varied from 37.69±4.08 to 48.73±5.62 N, which indicated that the tablets had sufficient mechanical integrity to withstand packaging and carrying. Results showed that Formulation (F) 2, containing 5% sodium carboxymethyl... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Orally disintegrating tablets; Disintegration time; Mosapride citrate; Dogs; Superdisintegrant. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016001102064 |
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