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| Gorgisen,Gokhan; Hapil,Fatma Zehra; Yilmaz,Ozlem; Cetin,Zafer; Pehlivanoglu,Suray; Ozbudak,Irem Hicran; Erdogan,Abdullah; Ozes,Osman Nidai. |
| Abstract Lung cancer is the leading cause of cancer-related death, and NSCLC constitutes nearly 85%–90% of all cases. The IRS proteins function as adaptors and transmit signals from multiple receptors. Upon binding of insulin to the insulin receptor (IR), IRS1 is phosphorylated at several YXXM motifs creating docking sites for the binding of PI3Kp85, which activates AKT kinase. Therefore, we thought that gain of function mutantions of IRS1 could be related to development of lung cancer. In line with this, we wanted determine whether the IRS1 gene was mutated in the coding regions surrounding YXXM motifs. We sequenced the coding regions surrounding YXXM motifs of IRS1 using tumor samples of 42 NSCLC patients and 40 matching controls and found heterozygote... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: IRS1; NSCLC; Insulin signaling; Lung cancer; IRS proteins. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000100015 |
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