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| Cheng,Zhongzhe; Xie,Ming; Zhang,Wenjie; Cheng,Lan; Du,Yang; Wang,Yunjiao; Ying,Xixiang; Kang,Tingguo. |
| The objective of the present study was to develop a simple and selective HPLC method for the simultaneous determination of hesperidin (HP), caffeic acid (CA), ferulic acid (FA) and p-coumaric acid (p-CA) in rat plasma after intravenous administration of Portulaca oleracea L. extract (POE). With the hyperoside as the internal standard, the sample pretreatment procedure involved simple single-step extraction with methanol of 0.2 mL plasma. The mobile phase consisted of methanol-acetonitrile-tetrahydrofuran-0.5% glacial acetic acid (5:3:18:74, v/v/v/v). The calibration curves were linear over the range of 0.1-25 µg mL-1, 0.1-25 µg mL-1, 0.1-25 µg mL-1and 0.015-3 µg mL-1 for HP, CA, FA and p-CA, respectively. The method developed was suitable for the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Portulaca oleracea L./pharmacognosy; High Performance Liquid Chromatography/rat plasma; Vegetal extract/pharmacokinetic study; Medicinal plants. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000100018 |
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| Xue,Hefei; Li,Yuzhong; Zhang,Wenjie; Lu,Dongrui; Chen,Yinghui; Yin,Jingjing; Meng,Yihan; Ying,Xixiang; Kang,Tingguo. |
| The aim of this study is to develop a simple and specific HPLC method using vitexin as the internal standard to investigate the pharmacokinetics of isoquercitrin (ISOQ) after three different doses administrated intravenously to rats. The pharmacokinetic parameters were calculated by both compartmental and non-compartmental approaches. The results showed that ISOQ fitted a three-compartment open model. The values of AUC increased proportionally within the range of 5-10 mg·kg-1. Moreover, a half-life, b half-life, ªCL, MRT0-t and MRT0→∞ of ISOQ in rats showed significant differences between 20 mg·kg-1 and other doses, indicating that ISOQ presented dose-dependent pharmacokinetics in the range of 5-10 mg·kg-1 and non-linear pharmacokinetics at... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Isoquercitrin/pharmacokinetics; Isoquercitrin/experimental study; High Performance Liquid Chromatography; Crataegus pinnatifida Bge; Var major/leaves; Var major/phytochemistry. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300005 |
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| Qu,Gonglin; Xu,Liang; Zhang,Wenjie; Ying,Xixiang. |
| The novel alkaloid, oleracimine, presented remarkable anti-inflammatory bioactivity, and therefore, its pharmacokinetics was investigated in rat plasma after intravenous and oral administration by using a rapid ultra-high-performance liquid chromatography (UHPLC) method with UV detection at 270 nm. The analysis was performed on a shim-pack ODS column (75 mm×2 mm, 1.6 µm particle size, Shimadzu, Japan) column using isocratic elution with a mobile phase consisting of methanol-water (62:38, v/v) within 3 min. The results indicated that oleracimine was rapidly distributed with Tmax for 11.7 min after oral administration, which presented the double-peak phenomenon in the pharmacokinetic profile with a higher oral absolute bioavailability of 55.1% ± 7.83%. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Portulaca oleracea L./Oleracimine; Ultra-High-Performance Liquid Chromatography/Rat plasma; Pharmacokinetics. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400611 |
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| Zhang,Wenjie; Li,Di; Leng,Aijing; Ai,Junjun; Du,Yang; Meng,Yihan; Gao,Yucong; Ying,Xixiang. |
| The aim of the present study was to investigate the tissue distribution and excretion of five components of Portulaca oleracea L. extract (POE) in rat following oral administration. A rapid, sensitive and specific ultra-high performance liquid chromatography (UHPLC) method with puerarin as the internal standard was used for the quantitative analysis of five components of POE, including caffeic acid (CA), p-coumaric acid (p-CA), ferulic acid (FA), quercitrin (QUER) and hesperidin (HP) in rat tissues including the liver, intestine, stomach, muscle, heart, lung, brain, kidney and spleen, urine and feces. The results show that onlyp-CA and FA were found in nearly all tissues with low cumulative ratios, and CA was higher in the intestine and stomach with a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Portulaca oleracea L./pharmacokinetics; Portulaca oleracea L./extract/experimental study; Portulaca oleracea L./extract/ tissue distribution; Portulaca oleracea L./extrato/excretion; Compostos fenólicos; Ultra performance liquid chromatography/quantitative analysis. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300643 |
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