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| Yu,Cheng Hao; Zhao,Jin Shuang; Zhao,Hui; Peng,Teng; Shen,Dong Cheng; Xu,Qiu Xia; Li,Yao; Webb,R. Clinton; Wang,Mong Heng; Shi,Xing Ming; Peng,Cheng; Ding,Wei Jun. |
| The aim of this study was to elucidate the concise effects of a traditional herb pair, Curcumae rhizoma-Sparganii rhizoma (CRSR), on uterine leiomyoma (UL) by analyzing transcriptional profiling. The UL rat model was made by intramuscular injection of progesterone and gavage administration of diethylstilbestrol. From 11 weeks of the establishment of the model, rats of the UL+CRSR group were gavaged daily with CRSR (6.67 g/kg). The serum concentrations of progesterone (P) and estradiol (E2) were determined by radioimmunoassay, the uterine index was measured by caliper measurement, and the pathological status was observed by hematoxylin and eosin stain. Gene expression profiling was checked by NimbleGen Rat Gene Expression Microarrays. The results indicated... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Uterine leiomyoma; Transcriptional profiling; Extracellular matrix; Curcumae rhizoma; Sparganii rhizoma. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000600606 |
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