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Cellular Responses in the Respiratory Tract Following Intranasal administration of Peste des petits Ruminant Vaccine in Goats International Journal of Morphology
Ezeasor,C. V; Emikpe,B. O; Yussof,Sabri M; Afusat,Jagun; Anosa,V. O.
A trial was conducted to compare the cellular responses in the respiratory tract in intranasal vaccination against caprine Peste des petits ruminant lineage 1 variant virus infection with intramuscular and subcutaneous vaccinations in order to elucidate the mechanism of the protection. Twenty four goats were divided into four equal groups. Group 1 was vaccinated intranasaly, group 2 was vaccinated subcutaneously, and group 3 intramuscularly, while Group 4 was the unvaccinated control group. In each group the vaccinations were carried out once. All goats were challenged intratrachealy with PPR virus at a concentration of 106.5 TCID50 two weeks after vaccination and were euthanised 21 days after the challenge. The bronchoalveolar lavage differential count,...
Tipo: Journal article Palavras-chave: Cellular responses; Intranasal administration; Peste des petits ruminant vaccine; Goats.
Ano: 2013 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000200056
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