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Imbalance of γδT17/γδTreg cells in the pathogenesis of allergic asthma induced by ovalbumin BJMBR
Yang,Xia; Zhang,Jing-Hong; Deng,Wang-Sheng; Li,Chao-Qian.
We aimed to explore the imbalance between the T helper 17 γδT cells (γδT17) and the regulatory γδT cells (γδTreg) in asthmatic mice. Male Balb/c mice were randomly divided into the normal control group and the asthmatic model group. The asthmatic model group mice were intraperitoneally injected with the mixture of ovalbumin (OVA)/Al(OH)3 and then activated by exposure of the animals to OVA atomization. Airway hyperresponsiveness (AHR) was determined by a non-invasive lung function machine. Hematoxylin and eosin and Alcian blue-periodic acid Schiff staining were done for histopathological analysis. Interleukin (IL)-17 and IL-35 levels in bronchoalveolar lavage fluid were detected by ELISA. The percentage of IL-17+ γδT cells and Foxp3+ γδT cells in spleen...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bronchial asthma; ΓδT17 cells; ΓδTreg cells; Airway inflammation.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000900604
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