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	Provedor de dados BJMBR (2) Autor Zhang,Y.C. (2) Cui,S.Q. (1) Dong,P.X. (1) Fu,C.H. (1) Gu,X.L. (1) Shen,J.C. (1) Sun,H.W. (1) Wang,Q. (1) Wang,X.M. (1) Xiao,B. (1) Zhao,M.F. (1) Zheng,Y. (1) Mais... Palavra-chave Bone marrow (1) Chronic alcohol poisoning (1) Deferasirox (1) Hematopoietic stem/progenitor cells (1) Inflammatory factors (1) Iron overload (1) Microglia (1) N-acetyl-L-cysteine (1) Neuroprotection (1) Puerarin (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2017 (1) 2015 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Puerarin protects against damage to spatial learning and memory ability in mice with chronic alcohol poisoning BJMBR Cui,S.Q.; Wang,Q.; Zheng,Y.; Xiao,B.; Sun,H.W.; Gu,X.L.; Zhang,Y.C.; Fu,C.H.; Dong,P.X.; Wang,X.M.. We evaluated the effect of puerarin on spatial learning and memory ability of mice with chronic alcohol poisoning. A total of 30 male C57BL/6 mice were randomly divided into model, puerarin, and control groups (n=10 each). The model group received 60% (v/v) ethanol by intragastric administration followed by intraperitoneal injection of normal saline 30 min later. The puerarin group received intragastric 60% ethanol followed by intraperitoneal puerarin 30 min later, and the control group received intragastric saline followed by intraperitoneal saline. Six weeks after treatment, the Morris water maze and Tru Scan behavioral tests and immunofluorescence staining of cerebral cortex and hippocampal neurons (by Neu-N) and microglia (by Ib1) were conducted.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Puerarin; Chronic alcohol poisoning; Neuroprotection; Microglia; Inflammatory factors. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000600515 Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow BJMBR Shen,J.C.; Zhang,Y.C.; Zhao,M.F.. Using an iron overload mouse model, we explored the protective effect of deferasirox (DFX) and N-acetyl-L-cysteine (NAC) on injured bone marrow hematopoietic stem/progenitor cells (HSPC) induced by iron overload. Mice were intraperitoneally injected with 25 mg iron dextran every 3 days for 4 weeks to establish an iron overload (Fe) model. DFX or NAC were co-administered with iron dextran in two groups of mice (Fe+DFX and Fe+NAC), and the function of HSPCs was then examined. Iron overload markedly decreased the number of murine HSPCs in bone marrow. Subsequent colony-forming cell assays showed that iron overload also decreased the colony forming capacity of HSPCs, the effect of which could be reversed by DFX and NAC. The bone marrow hematopoiesis damage... Tipo: Info:eu-repo/semantics/article Palavras-chave: Iron overload; Bone marrow; Hematopoietic stem/progenitor cells; Deferasirox; N-acetyl-L-cysteine. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001200613 Registros recuperados: 2 Primeira ... 1 ... Última

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