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CTLA4 enhances the osteogenic differentiation of allogeneic human mesenchymal stem cells in a model of immune activation BJMBR
Dai,F.; Zhang,F.; Sun,D.; Zhang,Z.H.; Dong,S.W.; Xu,J.Z..
Allogeneic mesenchymal stem cells (allo-MSCs) have recently garnered increasing interest for their broad clinical therapy applications. Despite this, many studies have shown that allo-MSCs are associated with a high rate of graft rejection unless immunosuppressive therapy is administered to control allo-immune responses. Cytotoxic T-lymphocyte-associated protein 4 (CTLA4) is a co-inhibitory molecule expressed on T cells that mediates the inhibition of T-cell function. Here, we investigated the osteogenic differentiation potency of allo-MSCs in an activated immune system that mimics the in vivo allo-MSC grafting microenvironment and explored the immunomodulatory role of the helper T cell receptor CTLA4 in this process. We found that MSC osteogenic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: CTLA4; Mesenchymal stem cells; Immunomodulatory; Bone tissue engineering.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000700629
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Niemann-Pick type C1 protein influences the delivery of cholesterol to the SREBP: SCAP complex BJMBR
Guo,Y.J.; Li,W.H.; Wu,R.; Xie,Q.; Zhang,Z.H.; Cui,L.Q..
Tipo: Info:eu-repo/semantics/article
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000100005
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Aqueous tissue extracts of Conyza canadensis inhibit the germination and shoot growth of three native herbs with no autotoxic effects Planta Daninha
Hu,G.; Zhang,Z.H..
Conyza canadensis is a widespread weed species forming dense populations in most regions of China. Petri dish bioassays with aqueous extracts of the aboveground parts and roots of C. canadensis at three concentrations (0.05, 0.1, and 0.2 g mL-1) were undertaken to investigate the autotoxic effects of C. canadensis, and the possible effects on three dominant native weed species, Plantago asiatica, Digitaria sanguinalis and Youngia japonica. The results showed that seed germination and the shoot length of three native species were significantly inhibited by aqueous extracts of C. canadensis at almost all concentrations that generally increased with increasing extract concentration. However, the seed germination and shoot length of C. canadensis itself was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Invasive alien weed; Allelopathy; Petri dish bioassay.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582013000400006
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