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	Provedor de dados BJMBR (1) Autor Li,Zhou (1) Liu,Ying (1) Song,Zhiqi (1) Wang,Yupeng (1) Zhao,Guangming (1) Zhou,Wenhui (1) Mais... Palavra-chave Melanogenesis (1) Metabotropic glutamate receptor-4 (1) Th17 (1) Vitiligo (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2020 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Critical role of metabotropic glutamate receptor 4 in bone marrow-derived dendritic cells in the Th17 cell differentiation and the melanogenesis of B16 cells BJMBR Zhao,Guangming; Zhou,Wenhui; Liu,Ying; Wang,Yupeng; Li,Zhou; Song,Zhiqi. Vitiligo is an acquired pigmentary disorder resulting from selective destruction of melanocytes. Emerging studies have suggested that T helper cell 17 (Th17) is potentially implicated in vitiligo development and progression. It was recently discovered that metabotropic glutamate receptor 4 (mGluR4) can modulate Th17-mediated adaptive immunity. However, the influence of mGluR4 on melanogenesis of melanocytes has yet to be elucidated. In the present study, we primarily cultured mouse bone marrow-derived dendritic cells (BMDC) and then knocked down and over-expressed mGluR4 using transfection. Transduced BMDC were co-cultured with CD4+ T cells and the expression of Th17-related cytokines were measured. The morphology and melanogenesis of B16 cells were... Tipo: Info:eu-repo/semantics/article Palavras-chave: Metabotropic glutamate receptor-4; Th17; Melanogenesis; Vitiligo. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000400604 Registros recuperados: 1 Primeira ... 1 ... Última

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