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Gene expression profiling reveals upregulated FUT1 and MYBPC1 in children with pancreaticobiliary maljunction BJMBR
Guo,Wan-Liang; Geng,Jia; Zhao,Jun-gang; Fang,Fang; Huang,Shun-Gen; Wang,Jian.
Pancreaticobiliary maljunction (PBM) is associated with high risk of epithelial atypical growth and malignant transformation of the bile duct or gallbladder. However, overall changes in genetic expression have not been examined in children with PBM. Genome-wide expression was analyzed using peripheral blood samples from 10 children with PBM and 15 pediatric controls. Differentially expressed genes (DEGs) were identified using microarray. Bioinformatics analysis was conducted using Gene Ontology and KEGG analyses. The top 5 in the up-regulated genes in PBM were verified with qRT-PCR. Receiver operator characteristic curve analysis was conducted to evaluate the predictive accuracy of selected genes for PBM. The microarray experiments identified a total of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pediatric; Pancreaticobiliary maljunction; Gene expression.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000800603
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