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	Provedor de dados Biocell (1) Autor Ba,Jing (1) Guo,Xiaolin (1) Zhao,Lianshuang (1) Zhou,Liping (1) Palavra-chave Cell migration (1) Hyaluronic acid (1) Lamellipodia formation (1) Uropod formation (1) Tipo do documento Info:eu-repo/semantics/report (1) Ano 2010 (1) País Argentina (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity Biocell Zhou,Liping; Guo,Xiaolin; Ba,Jing; Zhao,Lianshuang. CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL-12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest that CD44 participates in CXCL-12 induced cell polarization and subsequent cell migration. Tipo: Info:eu-repo/semantics/report Palavras-chave: Cell migration; Lamellipodia formation; Uropod formation; Hyaluronic acid. Ano: 2010 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452010000200005 Registros recuperados: 1 Primeira ... 1 ... Última

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