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| Wang,Meiling; Yang,Limin; Ji,Musi; Zhao,Pengwei; Sun,Peng; Bai,Ruixia; Tian,Yunpeng; Su,Liping; Li,Cunbao. |
| The current study was designed to evaluate the aqueous extract of Terminalia chebula activity, and the main pathway was detected on lung cancer by extracts of T. chebula. Aqueous extract of T. chebula was separated using a zeolite, and five fractions of T. chebula extract were obtained and analyzed by ultraviolet (UV) and infrared (IR) spectroscopy. Antiproliferative activity was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) methods against human lung cancer (A549) and mouse lung cancer cell line LLC. T. chebula acts by regulating the Bcl-2 family protein-mediated mitochondrial pathway detected by western blot. Fraction 4 of the T. chebula extract showed much function and was thus studied further. Fraction 4 increased the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: T. chebula; Aqueous extract; Infrared spectroscopy; Apoptosis. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000200208 |
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