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Clinicopathological significance of PTPN12 expression in human breast cancer BJMBR
Xunyi,Yuan; Zhentao,Yuan; Dandan,Jiang; Funian,Li.
Protein tyrosine phosphatase non-receptor type 12 (PTPN12) is a recently identified tumor suppressor gene (TSG) that is frequently compromised in human triple-negative breast cancer. In the present study, we investigated the expression of PTPN12 protein by patients with breast cancer in a Chinese population and the relationship between PTPN12 expression levels and patient clinicopathological features and prognosis. Additionally, we explored the underlying down-regulation mechanism from the perspective of an epigenetic alteration. We examined PTPN12 mRNA expression in five breast cancer cell lines using semi-quantitative reverse-transcription PCR, and detected PTPN12 protein expression using immunohistochemistry in 150 primary invasive breast cancer cases...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Breast cancer; Tumor suppressor gene; PTPN12; Prognosis; Methylation.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200033
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