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	Provedor de dados BJPS (1) Autor Linden,Rafael (1) Souto,André Arigony (1) Tonello,Paula (1) Wingert,Maína (1) Ziulkoski,Ana Luiza (1) Palavra-chave CYP2C19 gene (1) Metabolic genotyping (1) Metabolic phenotyping (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2009 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Relation between CYP2C19 phenotype and genotype in a group of Brazilian volunteers BJPS Linden,Rafael; Ziulkoski,Ana Luiza; Tonello,Paula; Wingert,Maína; Souto,André Arigony. The CYP2C19 gene presents polymorphism affecting the pharmacokinetics of several drugs of clinical importance. The purpose of this study was to investigate the correlation between CYP2C19 genotype and metabolic phenotype in a group of 38 Brazilian volunteers, evaluating the phenotype prediction capacity of the genotyping procedure. For CYP2C19 phenotyping, omeprazole was used as the probe drug, using the hydroxylation metabolic ratio as the phenotypic indicator. Venous blood samples were drawn before and three hours after an oral administration of 20 mg omeprazole. The plasma concentrations of omeprazole and hydroxy-omeprazole were determined by high performance liquid chromatography. The genotyping assay was carried out using a Real-Time-PCR-based assay,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Metabolic phenotyping; Metabolic genotyping; CYP2C19 gene. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300011 Registros recuperados: 1 Primeira ... 1 ... Última

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