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	Provedor de dados BJPS (2) Autor Huang,Ming (2) Zhang,Quan-ying (2) Zong,Shun-lin (2) Lv,Cheng-zhe (1) Wang,Meng (1) Palavra-chave China. (1) Diacerein capsule/pharmacokinetics (1) HPLC-MS/MS (1) High fat and calories diet (1) Multiple dose (1) Repirinast/safety/pharmacokinetics (1) Single dose (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (1) 2018 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Pharmacokinetics and safety of repirinast tablets in healthy Chinese subjects BJPS Lv,Cheng-zhe; Huang,Ming; Zhang,Quan-ying; Zong,Shun-lin; Wang,Meng. ABSTRACT Repirinast is a new, synthetic, disodium cromoglycate-like antiallergic agent for oral administration in humans. This study evaluated the safety, tolerability and pharmacokinetics of repirinast tablets in healthy Chinese volunteers. This was a phase I, open-label, randomized, single- and multiple-dose study. Subjects were assigned to receive a single dose of repirinast tablet at either 150, 300, or 450 mg, or multiple doses of 150 mg twice daily for 5 days. Plasma samples were analyzed with LC-MS/MS. Pharmacokinetic parameters of active metabolite MY-1250 (deesterified repirinast) were calculated using non-compartmental analysis with WinNonlin software. Statistical analysis was performed using SPSS software. All adverse events (AEs) were mild and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Repirinast/safety/pharmacokinetics; Single dose; Multiple dose; China.. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200625 The effect of food intake on the pk of rhein released from diacerein BJPS Huang,Ming; Zong,Shun-lin; Zhang,Quan-ying. Diacerein is a symptomatic slow-acting drug used for treating osteoarthritis. This drug is completely metabolized into the active metabolite rhein before reaching the systemic circulation. This study evaluated the effects of food on the pharmacokinetics of rhein released from diacerein in healthy Chinese subjects. This was a single-center, randomized, single-dose, open-label, two-period, cross-over study. Twenty-four healthy subjects were randomly selected to receive a single oral dose of 50 mg diacerein capsule in either fasted or fed state on two separate visits. Plasma samples were analyzed with LC-MS/MS. Pharmacokinetic parameters were calculated using WinNonlin software. In the fasted and fed states, the main pharmacokinetic parameters of diacerein... Tipo: Info:eu-repo/semantics/article Palavras-chave: Diacerein capsule/pharmacokinetics; HPLC-MS/MS; High fat and calories diet. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100544 Registros recuperados: 2 Primeira ... 1 ... Última

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