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| Botton,Mariana R.; Viola,Patrícia P.; Meireles,Mariana R.; Bruxel,Estela M.; Zuchinali,Priccila; Bandinelli,Eliane; Rohde,Luis E.; Leiria,Tiago L. L.; Salamoni,Joyce Y. Y.; Garbin,Arthur P.; Hutz,Mara H.. |
| Abstract Warfarin is an oral anticoagulant prescribed to prevent and treat thromboembolic disorders. It has a narrow therapeutic window and must have its effect controlled. Prothrombin test, expressed in INR value, is used for dose management. Time in therapeutic range (TTR) is an important outcome of quality control of anticoagulation therapy and is influenced by several factors. The aim of this study was to identify genetic, demographic, and clinical factors that can potentially influence TTR. In total,422 patients using warfarin were investigated. Glibenclamide co-medication and presence of CYP2C9*2 and/or *3 alleles were associated with higher TTR, while amiodarone, acetaminophen and verapamil co-medication were associated with lower TTR. Our data... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: CYP2C9; VKORC1; ASPH; TTR; Warfarin. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000300302 |
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