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| Souza,M.M. de; Silva,L.M.; Barbosa Jr.,A.A.; de Oliveira,I.R.; Paraná,R.; Andrade,Z.A.. |
| Rats infected with the helminth Capillaria hepatica regularly develop septal hepatic fibrosis that may progress to cirrhosis in a relatively short time. Because of such characteristics, this experimental model was selected for testing drugs exhibiting antifibrosis potential, such as pentoxifylline, gadolinium chloride and vitamin A. Hepatic fibrosis was qualitatively and quantitatively evaluated in liver samples obtained by partial hepatectomy and at autopsy. The material was submitted to histological, biochemical and morphometric methods. A statistically significant reduction of fibrosis was obtained with pentoxifylline when administered intraperitoneally rather than intravenously. Gadolinium chloride showed moderate activity when administered... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Capillaria hepatica; Hepatic fibrosis; Septal fibrosis; Antifibrotic drugs. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100011 |
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