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| Rudd,T.R.; Hughes,A.; Holman,J.; Solari,V.; de Oliveira Ferreira,E.; Cavalcante Pilotto Domingues,R.M.; Yates,E.A.. |
| Heparan sulphate (HS) and the related polysaccharide, heparin, exhibit conformational and charge arrangement properties, which provide a degree of redundancy allowing several seemingly distinct sequences to exhibit the same activity. This can also be mimicked by other sulphated polysaccharides, both in overall effect and in the details of interactions and structural consequences of interactions with proteins. Together, these provide a source of active compounds suitable for further development as potential drugs. These polysaccharides also possess considerable size, which bestows upon them an additional useful property: the capability of disrupting processes comprising many individual interactions, such as those characterising the attachment of microbial... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Heparan sulfate; Biosynthesis; Structure-function; Microbial attachment. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000500002 |
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