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| de Oliveira Uehara,Silvia Naomi; Emori,Christini Takemi; Perez,Renata Mello; Mendes-Correa,Maria Cassia Jacintho; de Souza Paiva Ferreira,Adalgisa; de Castro Amaral Feldner,Ana Cristina; Silva,Antonio Eduardo Benedito; Filho,Roberto José Carvalho; de Souza e Silva,Ivonete Sandra; Ferraz,Maria Lucia Cardoso Gomes. |
| Abstract Brazil is one of the 22 countries that concentrates 80% of global tuberculosis cases concomitantly to a large number of hepatitis C carriers and some epidemiological risk scenarios are coincident for both diseases. We analyzed tuberculosis cases that occurred during α-interferon-based therapy for hepatitis C in reference centers in Brazil between 2001 and 2012 and reviewed their medical records. Eighteen tuberculosis cases were observed in patients submitted to hepatitis C α-interferon-based therapy. All patients were human immunodeficiency virus-negative. Nine patients (50%) had extra-pulmonary tuberculosis; 15 (83%) showed significant liver fibrosis. Hepatitis C treatment was discontinued in 12 patients (67%) due to tuberculosis reactivation and... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Hepatitis C; Tuberculosis; Alpha-interferon; Latent tuberculosis infection. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200205 |
