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| CUDDON,PAUL; BOOTMAN,MARTIN D; RICHARDS,GILLIAN R; SMITH,ALISON J; SIMPSON,PETER B; RODERICK,H LLEWELYN. |
| Neurons are a diverse cell type exhibiting hugely different morphologies and neurotransmitter specifications. Their distinctive phenotypes are established during differentiation from pluripotent precursor cells. The signalling pathways that specify the lineage down which neuronal precursor cells differentiate remain to be fully elucidated. Among the many signáis that impinge on the differentiation of neuronal cells, cytosolic calcium (Ca2+) has an important role. However, little is known about the nature of the Ca2+ signáis involved in fate choice in neuronal precursor cells, or their sources. In this study, we show that activation of either muscarinic or platelet-derived growth factor (PDGF) receptors induces a biphasic increase in cytosolic Ca2+ that... |
| Tipo: Journal article |
Palavras-chave: Ca2+; PDGF; Methacholine; TRPC6; SOCE; Human neurosphere-derived cells. |
| Ano: 2008 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000200008 |
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| MACKENZIE,LAUREN; RODERICK,H. LLEWELYN; PROVEN,ANDREW; CONWAY,STUART J; BOOTMAN,MARTIN D. |
| Inositol 1,4,5-trisphosphate (InsP3) is an established calcium-mobilizing messenger, which is well-known to activate Ca2+ signaling in many cell types. Contractile cardiomyocytes express hormone receptors that are coupled to the production of InsP3. Such cardioactive hormones, including endothelin, may have profound inotropic and arrhythmogenic actions, but it is unclear whether InsP3 underlies any of these effects. We have examined the expression and localization of InsP3 receptors (InsP3Rs), and the potential role of InsP3 in modulating cardiac excitation-contraction coupling (EC coupling). Stimulation of electrically-paced atrial and ventricular myocytes with a membrane-permeant InsP3 ester was found to evoke an increase in the amplitudes of action... |
| Tipo: Journal article |
Palavras-chave: Calcium; Cardiac; Inositol; Arrhythmia; Ryanodine. |
| Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400008 |
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