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	Provedor de dados OAK (2) Autor Haneda, Masakazu (2) Nakamura, Kimihide (2) Yokohama, Shiro (2) Yoneda, Masashi (2) 中村, 公英 (2) Okada, Mitsuyoshi (1) Saito, Ako (1) Sato, Keisuke (1) Tamaki, Yosui (1) Mais... Palavra-chave Concanavalin A (2) Cytokine (2) Liver injury (2) Fucoidan (1) Kupffer cell (1) Scavenger receptor (1) T cell (1) Tolerance (1) Mais... Ano 2006 (2) País Japan (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Fucoidan prevents concanavalin A-induced liver injury through induction of endogenous IL-10 in mice OAK Saito, Ako; Yoneda, Masashi; Yokohama, Shiro; Okada, Mitsuyoshi; Haneda, Masakazu; Nakamura, Kimihide; 中村, 公英. Fucoidan is a complex of sulfated polysaccharides derived from non-mammalian origin such as marine brown algae and induces cytokine expression. We investigated the effect of fucoidan on concanavalin A (Con A)-induced liver injury in mice. Liver injury was induced by an intravenous injection of Con A (18.5 mg/kg). Various doses of fucoidan (1-30 mg/kg) were intravenously administered 30 min before Con A injection. The plasma alanine aminotransferase (ALT) and several cytokines levels were determined, and hepatic histological changes were also assessed. The effect of fucoidan administration by itself on induction of interleukin (IL)-10 in plasma and liver tissue was investigated. Con A administration induced an elevation of plasma ALT level, and fucoidan... Palavras-chave: Concanavalin A; Fucoidan; Liver injury; Cytokine; Kupffer cell; Scavenger receptor. Ano: 2006 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/66 Repeated administrations of concanavalin A induce Th1 to Th2 cytokine shift and tolerance against liver injury in mice OAK Tamaki, Yosui; Yoneda, Masashi; Sato, Keisuke; Yokohama, Shiro; Haneda, Masakazu; Nakamura, Kimihide; 中村, 公英. The intravenous injection of concanavalin A (Con A) activates T cells and induces cytokine dependent liver injury in mice. However, the effect of repeated administrations of Con A has not been fully investigated. Female BALB/c mice were intravenously injected with Con A (20 mg/kg) or saline once a week for six times. Mice were rechallenged with Con A 17 days after repeated administrations of Con A. Repeated Con A administrations elicited a sustained inhibition of rechallenged-Con A-induced liver injury. Plasma TNF-alpha and IFN-gamma levels after rechallenge of Con A were decreased compared with that of repeated saline treatments. By contrast, plasma IL-4 and IL-10 levels after rechallenge of Con A were increased. In spleen cells prepared from repeated Con... Palavras-chave: Concanavalin A; Tolerance; Cytokine; Liver injury; T cell. Ano: 2006 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/61 Registros recuperados: 2 Primeira ... 1 ... Última

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