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The role of autolysis loop in determining the specificity of coagulation proteases BJMBR
Yang,L.; Manithody,C.; Rezaie,A.R..
We recently demonstrated that the substitution of the autolysis loop (residues 143 to 154 in the chymotrypsin numbering system) of activated protein C (APC) with the corresponding loop of factor Xa (fXa) renders the APC mutant (APC/fX143-154) susceptible to inhibition by antithrombin (AT) in the presence of pentasaccharide. Our recent results further indicated, that in addition to an improvement in the reactivity of APC/fX143-154 with AT, both the amidolytic and anti-factor Va activities of the mutant APC have also been significantly increased. Since the autolysis loop of APC is five residues longer than the autolysis loop of fXa, it could not be ascertained whether this loop in the mutant APC specifically interacts with the activated conformation of AT or...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Activated protein C; Factor Va; Antithrombin; Factor Xa; Serpins.
Ano: 2007 URL:
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