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Design and evaluation of famotidine mucoadhesive nanoparticles for aspirin induced ulcer treatment BABT
Patel,Dhaval J; Patel,Jayvadan K.
The present study was performed to design and evaluate the famotidine loaded mucoadhesive nanosuspension for aspirin induced ulcer. A 3-factor, 3-level Box-Behnken design was applied to study the effects of amount of the beads (X1), PVPK-30(X2) and Tween-80 (X3) on the particle size (Y1), and cumulative percentage drug released after 1h (Y2). The optimization was performed using the desirability function and contour plots. The scanning electron microscopy (SEM) showed the nanoparticles as spherical in shape. The differential scanning calorimetry (DSC) analysis indicated that there was substantial crystallinity change in the nanoparticle compared with the pure drug. Ex-vivo mucoadhesion study showed that famotidine mucoadhesive nanoparticles possessed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Famotidine; Nanosuspension; Box-Behnken design; Mucoadhesion; Peptic ulcer.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000200007
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