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| Guimarães,Larissa O.; Andrade,Fabiana A. de; Bono,Gleyse F.; Setoguchi,Thaís E.; Brandão,Mariana B.; Chautard-Freire-Maia,Eleidi A.; Santos,Izabella C.R. dos; Picheth,Geraldo; Faria,Ana Cristina R. de A.; Réa,Rosângela R.; Souza,Ricardo L.R.; Furtado-Alle,Lupe. |
| Many conditions interfere with butyrylcholinesterase (BChE) activity, e.g., pregnancy or presence of the BCHE gene variant -116A can decrease activity whereas obesity and types I and II diabetes mellitus can increase activity. In this study, we examined BChE activity, -116A and 1615A BCHE gene variants, and anthropometric and biochemical variables associated with diabetes in patients with gestational diabetes mellitus (GDM) and in healthy pregnant women. BChE activity was measured spectrophotometrically using propionylthiocholine as substrate and genotyping of the -116 and 1615 sites of the BCHE gene was done with a TaqMan SNP genotyping assay. Three groups were studied: 150 patients with GDM, 295 healthy pregnant women and 156 non-pregnant healthy women.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Butyrylcholinesterase (BChE); Gestational diabetes mellitus; -116A variant; 1615A variant. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000100003 |
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