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| Biz,C.; Oliveira,C.; Mattos,A.B.M.; Oliveira,J.; Ribeiro,E.B.; Oller do Nascimento,C.M.; Oyama,L.M.. |
| Metabolic syndrome is associated with an increased risk of developing cardiovascular diseases and Plasminogen activator inhibitor 1 (PAI-1) overexpression may play a significant role in this process. A positive correlation between adipose tissue gene expression of PAI-1 and its serum concentration has been reported. Furthermore, high serum levels of thyroid hormones (T3 and T4) and PAI-1 have been observed in obese children. The present study evaluates the impact of thyroid hormone treatment on white adipose tissue PAI-1 gene expression and its serum concentration. Male Wistar rats (60 days old) were treated for three weeks with T4 (50 µg/day, Hyper) or with saline (control). Additionally, 3T3-L1 adipocytes were treated for 24 h with T4 (100 nM) or T3 (100... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Thyroid hormones; Plasminogen activator inhibitor 1; White adipose tissue; 3T3-L1. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001200007 |
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