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Interleukin 8 (-251 T>A) polymorphism in children and teenagers infected with Helicobacter pylori J. Venom. Anim. Toxins incl. Trop. Dis.
Saes,Marina; Labio,Roger Willian de; Rasmussen,Lucas Trevizani; Payão,Spencer Luiz Marques.
Abstract Background Helicobacter pylori (H. pylori) is a gram-negative bacterium that colonizes the human stomach and causes a variety of gastric diseases. This study evaluated the correlations between the -251 (T>A) (rs4073) polymorphism of interleukin-8 (IL-8), the etiology of gastric disease, and H. pylori infection in pediatric and adolescent patients. Methods DNA samples were obtained from 285 gastric biopsies from pediatric patients. H. pylori was detected by PCR, whereas PCR-RFLP was used to characterize the -251 (T>A) polymorphism of IL-8. Results The histological analysis revealed the presence of gastritis in 158 patients (55.44%). H. pylori was found in 71 samples (24.9%). The -251 (T>A) polymorphism revealed that 58 (29.47%)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Helicobacter pylori Interleukin 8 Polymorphism -251 (T> A) Gastric disease.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100601
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