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| El-demerdash, Amr; Moriou, Celine; Toullec, Jordan; Besson, Marc; Soulet, Stephanie; Schmitt, Nelly; Petek, Sylvain; Lecchini, David; Debitus, Cecile; Al-mourabit, Ali. |
| Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2–9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC50 values of 0.7 μM and 1.3 μM, respectively. |
| Tipo: Text |
Palavras-chave: Brominated tyrosine alkaloids; Suberea ianthelliformis; Cytotoxicity; Acetylcholinesterase inhibition. |
| Ano: 2018 |
URL: https://archimer.ifremer.fr/doc/00439/55076/56506.pdf |
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| Moriou, Céline; Lacroix, Damien; Petek, Sylvain; El-demerdash, Amr; Trepos, Rozenn; Leu, Tinihauarii Mareva; Florean, Cristina; Diederich, Marc; Hellio, Claire; Debitus, Cecile; Al-mourabit, Ali. |
| Chemical investigation of the South-Pacific marine sponge Suberea clavata led to the isolation of eight new bromotyrosine metabolites named subereins 1–8 (2–9) along with twelve known co-isolated congeners. The detailed configuration determination of the first representative major compound of this family 11-epi-fistularin-3 (11R,17S) (1) is described. Their chemical characterization was achieved by HRMS and integrated 1D and 2D NMR (nuclear magnetic resonance) spectroscopic studies and extensive comparison with literature data. For the first time, a complete assignment of the absolute configurations for stereogenic centers C-11/17 of the known members (11R,17S) 11-epi-fistularin-3 (1) and 17-deoxyfistularin-3 (10) was determined by a combination of... |
| Tipo: Text |
Palavras-chave: Sponge; Verongiida; Suberea clavata; Bromotyrosine; Fistularin-3; Acetylcholinesterase inhibition; Antifouling. |
| Ano: 2021 |
URL: https://archimer.ifremer.fr/doc/00684/79581/82258.pdf |
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| Guerrero,Ricardo O; Mahmud,T; Khan,H; Casañas,Bárbara; Morales,Mara. |
| Summary Bangladesh is an Asian country where only 20 per cent of the people are provided with modern healthcare services while the rest 80 per cent are dependent on traditional plant-based systems. Moreover, it is estimated that only 500 medicinal plant species had been recorded in Bangladesh out of 1,900 species regarded as having medicinal value. Purpose: Sixteen collections of medicinal plants of different families were extracted with several solvents (Ethanol 95%, water, chloroform, ethyl ether). The resulting extracts were subjected to five different specific bioassays: 1. Brine shrimp lethality test; 2. Antioxidant activity; 3. Inhibition of xanthine oxidase (XO); 4. Inhibition of ß-glucosidase, and 5. Inhibition of acetylcholinesterase. Methods.... |
| Tipo: Journal article |
Palavras-chave: Bangladesh; Plant extracts; Brine shrimp lethality test; Antioxidant activity; Xanthine oxidase inhibition; SS-glucosidase inhibition; Acetylcholinesterase inhibition. |
| Ano: 2004 |
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962004000200009 |
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| Peschiutta,M.L; Arena,J.S; Ramirez Sanchez,A; Gomez Torres,E; Pizzolitto,R.P; Merlo,C; Zunino,M.P; Omarini,A.B; Dambolena,J. S; Zygadlo,J. A. |
| The insecticidal and antifungal properties of Mexican oregano (Lippia graveolens) essential oil from the Dominican Republic were investigated under laboratory conditions against two main pests of stored grains: Sitophilus zeamais and Fusarium verticillioides. Although oregano essential oil at 600 μl/l air did not result in a significant mortality of S. zeamais after 24 hours of exposure by fumigation, this essential oil was a powerful acetylcholinesterase (AChE) inhibitor in vitro. One of the main components of oregano essential oil, p-cymene, presented fumigant toxicity and AChE inhibition activity against the maize weevil. The L. graveolens essential oil antifungal activity against F. verticillioides was evaluated at 50, 100 and 200 µl/l, and it... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acetylcholinesterase inhibition; Fungal pathogen; Lippia graveolens; Maize pest control; Maize weevil. |
| Ano: 2016 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1668-298X2016000200003 |
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| Lima,Matheus Thomaz Nogueira Silva; Santos,Larissa Batista dos; Bastos,Rafael Wesley; Nicoli,Jacques Robert; Takahashi,Jacqueline Aparecida. |
| ABSTRACT Major health challenges as the increasing number of cases of infections by antibiotic multiresistant microorganisms and cases of Alzheimer's disease have led to searching new control drugs. The present study aims to verify a new way of obtaining bioactive extracts from filamentous fungi with potential antimicrobial and acetylcholinesterase inhibitory activities, using epigenetic modulation to promote the expression of genes commonly silenced. For such finality, five filamentous fungal species (Talaromyces funiculosus, Talaromyces islandicus, Talaromyces minioluteus, Talaromyces pinophilus, Penicillium janthinellum) were grown or not with DNA methyltransferases inhibitors (procainamide or hydralazine) and/or a histone deacetylase inhibitor... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antimicrobial activity; Acetylcholinesterase inhibition; Epigenetic modulation; Penicillium sp.; Talaromyces sp.. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000100169 |
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