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	Provedor de dados BJPS (1) Autor Aragão,Cícero Flávio Soares (1) Câmara,Manuela Bernardo (1) Dantas,Monique Gomes (1) Freire,Fátima Duarte (1) Lima e Moura,Túlio Flávio Accioly de (1) Raffin,Fernanda Nervo (1) Mais... Palavra-chave Acrycoat L 100(r)/use/enteric coating (1) Gastric-resistant isoniazids/pellets (1) Pellets/enteric coating (1) Rifampicin (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2014 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Gastric-resistant isoniazid pellets reduced degradation of rifampicin in acidic medium BJPS Freire,Fátima Duarte; Câmara,Manuela Bernardo; Dantas,Monique Gomes; Aragão,Cícero Flávio Soares; Lima e Moura,Túlio Flávio Accioly de; Raffin,Fernanda Nervo. Isoniazid and rifampicin are considered the first-line medication for preventing and treating tuberculosis. Rifampicin is degraded in the stomach acidic environment, especially when combined with isoniazid, factor contributing to treatment failure. In this study, gastric-resistant isoniazid pellets were obtained to physical contact of this drug with rifampicin and to bypass the stomach´s acidic environment. The pellets were fabricated using the extrusion-spheronization technique. The coating process was conducted in a fluid spray coater using Acrycoat L 100(r) solution as the coating agent. The pellets obtained were submitted to a dissolution test in HCl 0.1 N and phosphate buffer media. The results indicated that optimum gastric-resistance was only... Tipo: Info:eu-repo/semantics/article Palavras-chave: Rifampicin; Gastric-resistant isoniazids/pellets; Pellets/enteric coating; Acrycoat L 100(r)/use/enteric coating. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400749 Registros recuperados: 1 Primeira ... 1 ... Última

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