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| Sánchez Rodríguez,Nora; Bu Wong,Margarita; Pérez-Saad,Héctor Manuel; León Rodríquez,Niurka; García Salmán,Jorge Daniel. |
| INTRODUCCIÓN: Spirulina platensis es una microalga verde-azul de alto valor nutricional, la cual ha sido empleada como suplemento dietético. Varios de sus constituyentes ayudan al mantenimiento de la estructura y función de los tejidos nerviosos. OBJETIVO: determinar el efecto de esta microalga en un modelo de neuropatía axonal inducida por acrilamida, en ratones. MÉTODOS: el modelo consistió en la administración diaria de 70 mg/kg de acrilamida, por vía subcutánea, durante 3 semanas consecutivas; con la estimación del efecto neurotóxico de este compuesto mediante el registro, en los músculos de la pierna, del potencial de acción muscular compuesto, durante la estimulación supramáxima del nervio ciático. Después de finalizar las inyecciones de acrilamida,... |
| Tipo: Journal article |
Palavras-chave: Acrilamida; Nervio ciático; Neuropatía axonal; Neuroregeneración; Spirulina platensis; Acrylamide; Sciatic nerve; Axonal neuropathy; Neuroregeneration; Spirulina platensis. |
| Ano: 2009 |
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962009000100006 |
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| Zamani,Ehsan; Shokrzadeh,Mohammad; Modanloo,Mona; Shaki,Fatemeh. |
| ABSTRACT Acrylamide (AA), is an important industrial compound, formed during food processing under high temperature. Due to its potential carcinogenic effect, it has been recognized as a human health concern. In this study, we investigated the role of oxidative stress in acrylamide’s genotoxicity and protective role of L- carnitine (LCA) in human lymphocytes. The micronucleus test (MNT) was used to monitor AA genotoxicity after 20h exposure to concentrations of 0.25,50 and 100 mM. Furthermore we evaluated oxidative stress markers, such as reactive oxygen species (ROS), lipid peroxidation (LPO) and glutathione (GSH) content. In MNT, It has been found that AA at high concentrations (50 and 100 µM) significantly increased the micronuclei (MN) frequencies. On... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acrylamide; L- carnitine; Micronucleus; Oxidative stress; Genotoxicity. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100426 |
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| Cachumba,Jorge Javier Muso; Antunes,Felipe Antonio Fernandes; Peres,Guilherme Fernando Dias; Brumano,Larissa Pereira; Santos,Júlio César Dos; Silva,Silvio Silvério Da. |
| ABSTRACT L-asparaginase (EC 3.5.1.1) is an enzyme that catalysis mainly the asparagine hydrolysis in L-aspartic acid and ammonium. This enzyme is presented in different organisms, such as microorganisms, vegetal, and some animals, including certain rodent's serum, but not unveiled in humans. It can be used as important chemotherapeutic agent for the treatment of a variety of lymphoproliferative disorders and lymphomas (particularly acute lymphoblastic leukemia (ALL) and Hodgkin's lymphoma), and has been a pivotal agent in chemotherapy protocols from around 30 years. Also, other important application is in food industry, by using the properties of this enzyme to reduce acrylamide levels in commercial fried foods, maintaining their characteristics (color,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: L-asparaginase; Microbial production; Industrial production; Pharmaceutical application; Acrylamide. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000500077 |
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