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	Provedor de dados BJMBR (2) Autor Domenico,T. (1) Felipe,C.R. (1) Franco,M.F. (1) Garcia,R. (1) Gonçalves,L.F. (1) Joelsons,G. (1) Machado,P.G. (1) Manfro,R.C. (1) Medina-Pestana,J.O. (1) Park,S.I. (1) Spinelli,G.A. (1) Tedesco-Silva Jr.,H. (1) Mais... Palavra-chave Acute rejection (2) Kidney transplantation (2) Clinical trial (1) Diagnosis (1) Gene expression (1) MRNA (1) Mycophenolate mofetil (1) Sirolimus (1) Tacrolimus (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Non-invasive messenger RNA transcriptional evaluation in human kidney allograft dysfunction BJMBR Joelsons,G.; Domenico,T.; Gonçalves,L.F.; Manfro,R.C.. The aim of the present study was to evaluate messenger RNA expression in kidney allograft recipients. Forty-four kidney transplant recipients were evaluated up to three months after grafting. After transplantation, peripheral blood samples were drawn sequentially for real-time polymerase chain reaction analyses of perforin and TIM-3 genes. Biopsies were obtained to evaluate acute graft dysfunction and interpreted according to the Banff classification. Eight patients presented episodes of acute rejection. Recipients with rejection had significantly higher levels of TIM-3 mRNA transcripts compared to those without rejection (median gene expression 191.2 and 36.9 mRNA relative units, respectively; P<0.0001). Also, perforin gene expression was higher in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Kidney transplantation; Acute rejection; Gene expression; Diagnosis; MRNA. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000700608 Exploratory calcineurin inhibitor-free regimens in living-related kidney transplant recipients BJMBR Garcia,R.; Machado,P.G.; Felipe,C.R.; Park,S.I.; Spinelli,G.A.; Franco,M.F.; Tedesco-Silva Jr.,H.; Medina-Pestana,J.O.. Chronic allograft nephropathy is among the major causes of graft loss even in low-risk kidney transplant recipients and correlates with acute nephrotoxic events during the first year post-transplant. Therefore, calcineurin inhibitor-free regimens may improve patient and graft survival among recipients of living-related kidney transplants. To confirm this hypothesis, we evaluated the efficacy and safety of two calcineurin inhibitor-free regimens in 92 low-risk recipients of one-haplotype living-related kidney transplants. Immunosuppression consisted of tacrolimus, azathioprine and prednisone (group I, GI, N = 38), 2 doses of daclizumab, mycophenolate mofetil (MMF), and prednisone (GII, N = 33) and 2 doses of daclizumab, MMF, sirolimus and prednisone (GIII,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Tacrolimus; Mycophenolate mofetil; Sirolimus; Kidney transplantation; Acute rejection; Clinical trial. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000400003 Registros recuperados: 2 Primeira ... 1 ... Última

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