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Artificial neural network modeling studies to predict the yield of enzymatic synthesis of betulinic acid ester Electron. J. Biotechnol.
Moghaddam,Mansour Ghaffari; Ahmad,Faujan Bin H; Basri,Mahiran; Rahman,Mohd Basyaruddin Abdul.
3β-O-phthalic ester of betulinic acid was synthesized from reaction of betulinic acid and phthalic anhydride using lipase as biocatalyst. This ester has clinical potential as an anticancer agent. In this study, artificial neural network (ANN) analysis of Candida antarctica lipase (Novozym 435) -catalyzed esterification of betulinic acid with phthalic anhydride was carried out. A multilayer feed-forward neural network trained with an error back-propagation algorithm was incorporated for developing a predictive model. The input parameters of the model are reaction time, reaction temperature, enzyme amount and substrate molar ratio while the percentage isolated yield of ester is the output. Four different training algorithms, belonging to two classes, namely...
Tipo: Journal article Palavras-chave: Acylation; Artificial neural network; Betulinic acid; Candida antarctica lipase; Enzymatic synthesis; Novozym 435.
Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582010000300003
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Traditional and New methods for the Preparation of Diazocarbonyl Compounds Anais da ABC (AABC)
BURTOLOSO,ANTONIO C.B.; MOMO,PATRÍCIA B.; NOVAIS,GRAZIELE L..
ABSTRACT For many years diazocarbonyl compounds have been studied due to their versatility and usability in many chemical transformations. In this review, we summarize the traditional methods to prepare these compounds as well as the new methods and recent improvements in experimental procedures. Moreover, emergence of continuous flow techniques has allowed safer and environmentally friendly procedures for the handling of diazomethane and diazo compounds and will also be a topic in this review.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acylation; Diazocarbonyl; Diazocompounds; Diazo transfer; Synthetic methodology.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000200859
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