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	Provedor de dados BABT (1) Autor Araújo,Elaine Bortoleti de (1) Colturato,Maria Tereza (1) Muramoto,Emiko (1) Palavra-chave Adenocarcinomas (1) Protein radioiodination (1) Radiopharmaceuticals (1) VIP (1) VIP10-28 (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2005 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Comparative biodistribution profile of [131I]VIP and [131I]VIP10-28 BABT Colturato,Maria Tereza; Muramoto,Emiko; Araújo,Elaine Bortoleti de. Various tumor cells express significantly higher amounts of VIP receptors (VIPR) that provided the basis for the clinical use of radiolabeled VIP for the in vivo localization of tumors. This work studied the labeling of VIP and VIP10-28 with iodine-131 to compare the biological distribution of the labeled compounds in Nuce mice and the affinity for tumor cells. Both VIP and VIP10-28 peptides contain two tyrosine residues, in positions 10 and 22, that are theoretically equally susceptible to radioiodination employing oxidative electrophilic substitution using oxidizing agents like Chloramine T. Radiochemical purity of the reaction mixture was determined by electrophoresis and HPLC. The VIP peptide and the fragment were labeled with radioiodine with good... Tipo: Info:eu-repo/semantics/article Palavras-chave: Radiopharmaceuticals; Protein radioiodination; VIP; VIP10-28; Adenocarcinomas. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700012 Registros recuperados: 1 Primeira ... 1 ... Última

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