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	Provedor de dados BJID (1) Genet. Mol. Biol. (1) Autor Castro,Luiza Amaral de (1) Ferreira,Henrique Bunselmeyer (1) Pillay,Balakrishna (1) Pillay,Manormoney (1) Ramsugit,Saiyur (1) Palavra-chave Adhesin (2) Antigen (1) Curli pili (1) Host-pathogen interaction (1) Invasin (1) Mycobacterium tuberculosis (1) Porcine enzootic pneumoniae (1) Virulence (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2016 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última A preliminary survey of M. hyopneumoniae virulence factors based on comparative genomic analysis Genet. Mol. Biol. Ferreira,Henrique Bunselmeyer; Castro,Luiza Amaral de. Mycoplasma hyopneumoniae is the etiological agent of porcine enzootic pneumonia (PEP), a major problem for the pig industry. The mechanisms of M. hyopneumoniae pathogenicity allow to predict the existence of several classes of virulence factors, whose study has been essentially restricted to the characterization of adhesion-related and major antigenic proteins. The now available complete sequences of the genomes of two pathogenic and one non-pathogenic strain of M. hyopneumoniae allowed to use a comparative genomics approach to putatively identify virulence genes. In this preliminary survey, we were able to identify 118 CDSs encoding putative virulence factors, based on specific criteria ranging from predicted cell surface location or variation between... Tipo: Info:eu-repo/semantics/article Palavras-chave: Porcine enzootic pneumoniae; Virulence; Host-pathogen interaction; Antigen; Adhesin. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000200012 Evaluation of the role of Mycobacterium tuberculosis pili (MTP) as an adhesin, invasin, and cytokine inducer of epithelial cells BJID Ramsugit,Saiyur; Pillay,Balakrishna; Pillay,Manormoney. Abstract This study was undertaken in order to assess the involvement of Mycobacterium tuberculosis pili (MTP) as an adhesin, invasin, and cytokine inducer in the M. tuberculosis-epithelial cell interaction. A MTP-deficient strain of M. tuberculosis demonstrated a significant reduction of 69.39% (p = 0.047) and 56.20% (p = 0.033) in its ability to adhere to and invade A549 pulmonary epithelial cells, respectively, in comparison with the wild-type strain. Complementation of the MTP-deficient mutant restored its adhesion and invasion capacity back to the wild-type levels. Overall, it was found that similar concentrations of IL-1β, IL-4, IL-6, IL-8, G-CSF, IFN-γ, MCP-1, and TNF-α were induced in A549 cells infected with the MTP-proficient and MTP-deficient... Tipo: Info:eu-repo/semantics/article Palavras-chave: Mycobacterium tuberculosis; Curli pili; Adhesin; Invasin. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200160 Registros recuperados: 2 Primeira ... 1 ... Última

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