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p53 as a prognostic factor in adrenocortical tumors of adults and children BJMBR
Sredni,S.T.; Zerbini,M.C.N.; Latorre,M.R.; Alves,V.A.F..
Mutations of the tumor suppressor gene p53 have been considered to be important determinants in several kinds of human cancer. Accumulation of p53 protein has been reported to correlate with more aggressive clinical behavior in some neoplasms. The role of p53 expression in adrenal cortical tumors (ACT) has not been elucidated but some studies have suggested its correlation with malignant behavior. Our objective was to determine if there is a correlation between the expression of immunoreactive p53 and the biological behavior of ACT. Fifty-seven ACT (21 from children and 36 from adults) were evaluated for p53 expression by immunohistochemistry in formalin-fixed paraffin-embedded tissue and analyzed in terms of outcome. The p53 parameter was utilized...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Adrenal cortical tumors; Histology; P53; Immunohistochemistry.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000100004
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