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Participation of hepatic α/β-adrenoceptors and AT1 receptors in glucose release and portal hypertensive response induced by adrenaline or angiotensin II BJMBR
de Araújo,L.J.T.; Nagaoka,M.R.; Borges,D.R.; Kouyoumdjian,M..
It has been previously demonstrated that the hemodynamic effect induced by angiotensin II (AII) in the liver was completely abolished by losartan while glucose release was partially affected by losartan. Angiotensin II type 1 (AT1) and adrenergic (∝1- and β-) receptors (AR) belong to the G-proteins superfamily, which signaling promote glycogen breakdown and glucose release. Interactive relationship between AR and AT1-R was shown after blockade of these receptors with specific antagonists. The isolated perfused rat liver was used to study hemodynamic and metabolic responses induced by AII and adrenaline (Adr) in the presence of AT1 (losartan) and ∝1-AR and β-AR antagonists (prazosin and propranolol). All antagonists diminished the hemodynamic response...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Liver perfusion; Angiotensin II; Adrenaline; AT1R; Adrenoceptors.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200604
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Antivenom therapy: efficacy of premedication for the prevention of adverse reactions J. Venom. Anim. Toxins incl. Trop. Dis.
Morais,Victor.
Abstract: Antivenoms or antitoxins have been effectively used for more than a century. During this time, these products have always proven to be highly effective in the treatment of infections and envenomations. However, antivenoms did not exhibit good safety results in their initial applications. After many improvements, antivenoms have substantially better safety profiles but still have some side effects. Due to the occurrence of adverse reactions, the practice of using premedication with the intent to decrease side effects has become accepted or mandatory in many countries. The drugs used for premedication belong to the histamine H1 antagonist, glucocorticoid and catecholamine groups. Currently, this practice is being questioned due to low or...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Premedication; Snakebite accident; Adverse reactions; Hydrocortisone; Antihistaminic; Adrenaline.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100203
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Anaphylactic shock following the bite of a wild Kayan slow loris (Nycticebus kayan): implications for slow loris conservation J. Venom. Anim. Toxins incl. Trop. Dis.
Madani,George; Nekaris,K Anne-Isola.
Background Asian slow lorises (Nycticebus spp.) are one of few known venomous mammals, yet until now only one published case report has documented the impact of their venomous bite on humans. We describe the reaction of a patient to the bite of a subadult Nycticebus kayan, which occurred in the Mulu District of Sarawak in 2012.Findings Within minutes of the bite, the patient experienced paraesthesia in the right side of the jaw, ear and right foot. By 40 minutes, swelling of the face was pronounced. The patient was admitted to Mulu National Park Health Clinic/Klinik Kesihatan Taman Mulu Tarikh, at which time he was experiencing: swollen mouth, chest pain, mild abdominal pain, nausea, numbness of the lips and mouth, shortness of breath, weakness, agitation...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Anaphylaxis; Hypersensitivity; Systemic reaction; Malaysia; Adrenaline; Necrosis; Paresthesia; Animal bite; Mammal venom; Hematuria.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200604
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Regression of dark color in subterranean fishes involves multiple mechanisms: response to hormones and neurotransmitters Neotropical Ichthyology
Grempel,Renato Grotta; Trajano,Eleonora; Visconti,Maria Aparecida.
ABSTRACT Organisms with source-populations restricted to the subterranean biotope (troglobites) are excellent models for comparative evolutionary studies, due to their specialization to permanent absence of light. Eye and dark pigment regression are characteristics of most troglobites. In spite of the advance in knowledge on the mechanisms behind eye regression in cave fishes, very little is known about pigmentation changes. Studies were focused on three species of the genus Pimelodella. Exemplars of the troglobitic P. spelaea and P. kronei were compared with the epigean (surface) P. transitoria, putative sister-species of the latter. Melanophore areas and densities are significantly lower in the troglobitic species. Evaluating the in vitro response of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Adrenaline; Melanin Concentrating Hormone; Melanophores; Physiology of Pigmentation; Troglobitic Fish.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-62252020000200214
Registros recuperados: 4
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