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	Provedor de dados BJMBR (2) Autor Belló-Klein,A. (1) Biolo,A. (1) Chedid,N.G.B. (1) Clausell,N. (1) Díaz G.,L.E. (1) Martins,S. (1) Masuda,M.O. (1) Mazzotti,N.G. (1) Quintero H.,C.C. (1) Rohde,L.E. (1) Rosa,A.S. (1) Saraiva,R.M. (1) Mais... Palavra-chave Adrenergic receptor (2) Heart failure (2) Ca2+ channel (1) Hypertrophy (1) Infarction (1) Polymorphisms (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2006 (1) 2003 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última The role of adrenergic receptor polymorphisms in heart failure BJMBR Biolo,A.; Rosa,A.S.; Mazzotti,N.G.; Martins,S.; Belló-Klein,A.; Rohde,L.E.; Clausell,N.. The main function of the cardiac adrenergic system is to regulate cardiac work both in physiologic and pathologic states. A better understanding of this system has permitted the elucidation of its role in the development and progression of heart failure. Regardless of the initial insult, depressed cardiac output results in sympathetic activation. Adrenergic receptors provide a limiting step to this activation and their sustained recruitment in chronic heart failure has proven to be deleterious to the failing heart. This concept has been confirmed by examining the effect of ß-blockers on the progression of heart failure. Studies of adrenergic receptor polymorphisms have recently focused on their impact on the adrenergic system regarding its adaptive... Tipo: Info:eu-repo/semantics/article Palavras-chave: Heart failure; Adrenergic receptor; Polymorphisms. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001000003 Impaired beta-adrenergic response and decreased L-type calcium current of hypertrophied left ventricular myocytes in postinfarction heart failure BJMBR Saraiva,R.M.; Chedid,N.G.B.; Quintero H.,C.C.; Díaz G.,L.E.; Masuda,M.O.. Infarct-induced heart failure is usually associated with cardiac hypertrophy and decreased ß-adrenergic responsiveness. However, conflicting results have been reported concerning the density of L-type calcium current (I Ca(L)), and the mechanisms underlying the decreased ß-adrenergic inotropic response. We determined I Ca(L) density, cytoplasmic calcium ([Ca2+]i) transients, and the effects of ß-adrenergic stimulation (isoproterenol) in a model of postinfarction heart failure in rats. Left ventricular myocytes were obtained by enzymatic digestion 8-10 weeks after infarction. Electrophysiological recordings were obtained using the patch-clamp technique. [Ca2+]i transients were investigated via fura-2 fluorescence. ß-Adrenergic receptor density was... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ca2+ channel; Heart failure; Hypertrophy; Infarction; Adrenergic receptor. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000500012 Registros recuperados: 2 Primeira ... 1 ... Última

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